Pair Name	Ginsenoside Rb1, Apatinib
Disease Info	[ICD-11: 2B6E]	Hypopharyngeal carcinoma		Investigative
Biological Phenomena	Induction-->Immunomodulatory
Gene Regulation	Up-regulation	Expression	CD4	hsa920
	Down-regulation	Expression	CD8A	hsa925
	Down-regulation	Expression	HK2	hsa3099
	Down-regulation	Expression	KDR	hsa3791
	Down-regulation	Expression	PECAM1	hsa5175
	Down-regulation	Expression	SLC2A4	hsa6517
	Down-regulation	Expression	SOX5	hsa6660
In Vitro Model	FaDu	Hypopharyngeal squamous cell carcinoma	Homo sapiens (Human)	CVCL_1218
	Rca-B	Squamous cell carcinoma	Rattus norvegicus (Rat)	CVCL_5U48
Result	A combination of apatinib and G-Rb1 induced more tumor cell apoptosis and reduced cell proliferation than the individual drug treatment and promote antitumor immunity by enhancing immunomodulatory molecules. Thus, we believe that this study could serve as a valuable platform to assess the synergetic anticancer effects of the herbal as well as synthetic medicines.